The Death and Life of John F. Donovanwill carry on without Jessica Chastain.
Chastain reportedly played a ruthless gossip columnist and functioned as a primary antagonist.
(Scroll through Dolans post for the full statement)
It was an extremely difficult decision to make.

Credit: Lyla Films
I feel, toward Jessica, a very sincere love and great admiration.
All sorts of developments unfold during the shooting of a film, as we know.
For Donovan, it was the latter.
Shortly after Dolan shared the news, Chastain responded with an Instagram post of her own.
Darlings theres some #johnfdonovan news, she captioned a photo of her with Dolan on set.
Dont worry, I was informed in advance of [Xaviers] letter.
This has been handled with the upmost respect and love.
[Xavier], I am always impressed with your true committment to telling a story.
To be an artist in each moment, you move beyond past ideas and expectations.
I love you dearly and look forward to our future collaborations in life and art.