Clooney explains that the film, from a Coen Brothers script, is actually based on a true story.
When audiences understand that, they are very intrigued and very, very moved, he tells EW.
Moore says the tonal shift in the film is what appealed to her most about the project.
You start in this interesting, slightly comedic world and then it really devolves into a true noir.
It gets very, very dark, she says.
Clooney says the central themes of the outsider and blaming the other slightly shifted over time.
When we started working on the film, it really wasnt about race relations, he says.
It was basically about scapegoating Mexicans and Muslims.
The pair both agree the film is pertinent to the times were living in.
When something is happening to blame it on something else and not take responsibility for it yourself.
Watch the video above for more from Clooney and Moore.